Myocd CLIA Kit for Mouse(Mus musculus) | EIAab.comMyocd CLIA Kit for Mouse(Mus musculus)

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Index > Protein center > Myocd(Gene name) > Mouse

Myocd (Gene name),

Myocardin (Protein name ), MYCD_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Myocd(Bsac2;Mycd;Srfcp);

Protein name:

Myocardin;

Alternative:

SRF cofactor protein;Basic SAP coiled-coil transcription activator 2;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Interacts with MLLT7/FOXO4 (By similarity). Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation. Interacts (via C-terminal) with EP300 (via CREB-binding domain). Interacts with HDAC4 and HDAC5. Interacts with MEF2C.

Function:

Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters.

Subcellular Location:

Nucleus speckle Nuclear, with a punctate intranuclear pattern with exclusion from nuclei.

Protein Attributes:

Sequence length:

935

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

935:

FSNLTSSGPS | IFNIDFLDVT | DLNLNSPMDL | HLQQW

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q8VIM5

KEGG:

mmu:214384

String:

Q8VIM5

Pfam:

PF02755

UniGene:

Mm.32257

Uniprot:

Q8VIM5

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ELISA Kit for Mouse Myocardin

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E0535h

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96T

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ELISA Kit for Mouse Myocardin

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E0535p

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ELISA Kit for Mouse Myocardin

Cat.:

E0535r

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96T

ELISA Kit for Mouse Myocardin

Cat.:

E0535m

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96T

CLIA Kit for Mouse Myocardin

Cat.:

U0535h

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96T

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CLIA Kit for Mouse Myocardin

Cat.:

U0535p

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96T

CLIA Kit for Mouse Myocardin

Cat.:

U0535r

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96T

CLIA Kit for Mouse Myocardin

Cat.:

U0535m

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96T

Polyclonal Antibody for Mouse Myocardin

Cat.:

P0535Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Myocardin

Cat.:

P0535Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Myocardin

Cat.:

P0535Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Myocardin

Monoclonal Antibody for Mouse Myocardin

Protein for Mouse Myocardin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor."
Wang D.-Z. , Chang P.S. , Wang Z. , Sutherland L. , Richardson J.A. , Small E. , Krieg P.A. , Olson E.N.
Cell105:851-862(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION;INTERACTION WITH SRF;MUTAGENESIS OF 387-GLU--ARG-389 AND 408-ASP--LEU-410
tissue: Heart.
2.

"Potentiation of serum response factor activity by a family of myocardin-related transcription factors."
Wang D.-Z. , Li S. , Hockemeyer D. , Sutherland L. , Wang Z. , Schratt G. , Richardson J.A. , Nordheim A. , Olson E.N.
Proc. Natl. Acad. Sci. U.S.A.99:14855-14860(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SEQUENCE REVISION TO 1-128
3.

"Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis."
Ueyama T. , Kasahara H. , Ishiwata T. , Nie Q. , Izumo S.
Mol. Cell. Biol.23:9222-9232(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);TISSUE SPECIFICITY
strain: NIH Swiss.
4.

"An alternative splicing form of myocardin (BSAC2), myocardin A (BSAC2A)."
Sawada T. , Okazaki T. , Nakano H.
Submitted (2001-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain: C57BL/6.
tissue: Heart.
5.

"Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation."
Du K.L. , Ip H.S. , Li J. , Chen M. , Dandre F. , Yu W. , Lu M.M. , Owens G.K. , Parmacek M.S.
Mol. Cell. Biol.23:2425-2437(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
6.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C57BL/6J.
tissue: Embryonic heart.
7.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
8.

"Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes."
Yoshida T. , Sinha S. , Dandre F. , Wamhoff B.R. , Hoofnagle M.H. , Kremer B.E. , Wang D.-Z. , Olson E.N. , Owens G.K.
Circ. Res.92:856-864(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH SRF
9.

"Glycogen synthase kinase 3beta inhibits myocardin-dependent transcription and hypertrophy induction through site-specific phosphorylation."
Badorff C. , Seeger F.H. , Zeiher A.M. , Dimmeler S.
Circ. Res.97:645-654(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-454; SER-458; SER-462; SER-466; SER-624; SER-628; SER-632 AND SER-636
10.

"Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin."
Cao D. , Wang Z. , Zhang C.L. , Oh J. , Xing W. , Li S. , Richardson J.A. , Wang D.Z. , Olson E.N.
Mol. Cell. Biol.25:364-376(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH EP300; HDAC4 AND HDAC5
11.

"Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR."
Creemers E.E. , Sutherland L.B. , Oh J. , Barbosa A.C. , Olson E.N.
Mol. Cell23:83-96(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 2 AND 4);INTERACTION WITH MEF2C;FUNCTION
12.

"Phosphorylation of myocardin by extracellular signal-regulated kinase."
Taurin S. , Sandbo N. , Yau D.M. , Sethakorn N. , Kach J. , Dulin N.O.
J. Biol. Chem.284:33789-33794(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-812; SER-859; SER-866 AND THR-893;MUTAGENESIS OF SER-812; SER-859; SER-866 AND THR-893
13.

"Expression and functional activity of four myocardin isoforms."
Imamura M. , Long X. , Nanda V. , Miano J.M.
Gene464:1-10(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 4 AND 5);TISSUE SPECIFICITY OF ISOFORMS;FUNCTION

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